Exploring the Dynamics of Sleep Deprivation: Insights into Complete Blood Count and Coagulation Parameters in a Case-Control Study

Background. Te lack of preceding research in Sudan emphasizes the importance of this study, which contributes critical data tothe global understanding of sleep-related health efects. Tis study investigates the complex relationship between sleep deprivation and blood-related factors, particularly focusing on full blood count and coagulation parameters. Methods. From January to March 2022, a case-control study was conducted in Kosti, Sudan. A control group of 11 healthy 23–33-year-olds (6 men and 5 women) had regular sleep patterns. Six men and fve women ages 23–33 were chosen for this sleep-deprived case study. Te case group was deprived of sleep from 7:00 p.m. to 7:00 a.m. for three days and allowed to sleep normally during the day. Daily at 7:00 a.m., antecubital vein blood was drawn. Te ACL 7000 coagulation analyzer and Sysmex fully automated hematology analyzers were used for coagulation and whole blood count analysis. Data analysis included descriptive and inferential approaches like the Mann–Whitney U test for group comparisons. Results. Te study found no signifcant diferences in total white blood cell counts reported between case and control groups (p � 0.898). Te case group had a substantial drop in lymphocyte counts on day 3 (p � 0.016). Te third day showed signifcant diferences in neutrophil and eosinophil levels (p � 0.003 and 0.000, respectively). Te diference in hemoglobin and hematocrit on day 3 was statistically signifcant (p � 0.023). Platelet counts were stable. Both
groups’ prothrombin times were unafected. On all three days, groups had signifcant diferences in activated partial thromboplastin time (APTT) (p � 0.004). Terefore, the intrinsic coagulation system may have changed. Conclusion. Tis study
demonstrates the complex link between sleep deprivation, coagulation indicators, and complete blood count. Monitoring blood indicators in poor sleep helps explain fundamental mechanisms and medicinal implications.