Most diseases has deleterious clinical presentations that are highly discomforting to the patients,
often time the treatment and management of these symptoms with known drugs comes with
adverse side effects, hence the need for a natural remedy. This study explored the potential
therapeutic benefits of a flavonoid-rich extract from Carica papaya (FRECP) on experimental
models to study the ant-inflammation, anti-fever and pain relief efficacy. The anti-inflammatory
effect was studied using the carrageenan-induced paw oedemamodel. Acetic acid-induced
writhing and tail immersion models were utilised for the test for analgesia, whereas Brewer’s
yeast-induced and dinitrophenol models were used for the antipyretic study. Each of the 5
investigations involved the random allocation of thirty (30) albino rats into 5 groups, each
consisting of 6 animals. Groups 1 and 5 were given distilled water and the conventional
medication, whereas groups 2 to 4 received 100, 200, and 400 mg/kg of oral FRECP in each
research. The study's results indicated that the observed advantages, especially at the dosage of
400 mg/kg, indicate that the flavonoid content of FRECP hinders crucial enzymes that play a role
in inflammation and the production of prostaglandins and decrease discomfort, and pyrexia in a
manner that depended on both the dosage and time of administration (p<0.05). We determined
that the flavonoid-rich extract of Carica papaya has pharmacological effects on inflammation,
pain, and fever.
Key words: Inflammation, Pain, Fever, Carica papaya, Therapeutic intervention.